**Please Note: ALL animal and pre-clinical work is performed by trained and certified BATTS Laboratories professionals with all corresponding permits in place.

 

Pre-Clinical (Animal Model Studies)

  • Immunization studies

  • Oncology

  • Non-GLP and GLP toxicology studies

  • Diabetes/obesity models

  • Pharmacokinetic studies

  • Immunotherapy studies

  • Bacterial and viral infection studies

  • Tissue and primary cell isolation

  • Transgenic colony breeding and maintenance

  • Customized model development

  • Histology, imaging and cell culture support

  • Dermal wound healing model

 

Cancer Xenograft

  • Model Selection and study design

  • In-vivo drug screening

  • mechanistic Studies

  • General technical reports (GTR) generated for IND filing

  • Cancer Xenograft Efficacy Models

  • Subcutaneous xenograft models (human tumors or cell lines transplanted into immuno-compromised rodents).

  • Commercial or client-produced cell lines

  • Orthotopic tumor models, which are cells implanted directly into the organs of interest.

  • Mammary fat pad (MFP) model

  • Renal capsule, spleen models

  • Prostate, ovarian models

 

Brain Tumor Models

  • Metastatic models, which are used for testing drugs that block metastases.

  • Forced metastatic models

  • Spontaneous metastatic models

  • Hu-SCID models, used with human immune system substitution in the development of antibody therapy and immunotherapy.

  • Human PBL grafts

  • Human immune organ grafts

  • Cord blood grafts

  • Syngeneic models - rodent tumors transplanted into hosts of the same genetic background to study immunotherapy and biological pathways.

  • Lewis lung carcinoma

 

Oncology Assays and Endpoints

  • Tumor size reduction and remission

  • Tumor growth delay

  • Decrease in metastases

  • Drug effects on host and tumor

  • Increase in the lifespan of the host

 

Diabetes

  • Diabetes and obesity drug development

  • Variety of animal metabolic models

  • Excellent technical and surgical capability

  • We can also assist you with:

  • Model selection and study design

  • In vivo drug screening

  • General technical report (GTR) generated for IND filing

  • Rodent Diabetes/Obesity Models

  • Genetic Models:

  • Many genetic changes can cause obesity and diabetic phenotypes. We use several commercially available models that are commonly used in diabetes/obesity research:

  • Zucker rat model

  • db/db mouse model

  • NOD mouse model

  • Non-Genetic Models

  • Diet induced obesity (DIO) model, a model for type II diabetes.

  • STZ (streptozotocin) induced diabetic model, for type I diabetes.

  • Assays and Endpoints

  • While a wide range of therapeutics have acute effects, others achieve their full effects after chronic treatment. 

  • BATTS Laboratory can help you design protocols that yield high-quality, meaningful data from every study. Common assays used in diabetes studies include:

  • In Vivo Assays for Glucose Metabolism

  • Resting Glucose levels

  • Glucose Tolerance Test (GTT)

  • Insulin Tolerance Test (ITT)

  • Additional Parameters

  • Clinical observations

  • Body weight

  • In-life collection of blood, serum, plasma, urine or feces for metabolite analysis

  • Necropsy with histopathology and immune staining

     

    BATTS Laboratory offers rodent models for wound healing studies. These mouse and rat full thickness excisional dermal models are commonly used to assess dermal wound healing processes, including granulation, tissue deposition, re-epithelialization and angiogenesis.

 

  • Dermal wound healing studies can be performed in normal healthy animals, as well as in animals with impaired wound healing. Impaired would healing is often performed in diabetic animals, such as db/db mice. In addition, agents such as steroids can also delay the wound healing process.

  • Dermal Wound Healing Efficacy Model

  • Excisional

  • Normal wound healing model – performed with normal animals

  • Impaired wound healing model - performed with diabetic animals

  • Delayed wound healing studies in mice and rats

  • Dermal DMPK

  • Pharmacokinetics/ toxicokinetics for dermal/ transdermal routes of administration

  • Extensive experience in wound healing studies

  • Excellent technical and surgical capability

 

Pharmacokinetics

Pharmacokinetic (PK) studies are a key aspect of the drug development process. Knowing how the body absorbs, distributes, metabolizes and eliminates drugs helps guide the dosing regimen to maximize efficacy and avoid undesirable effects.BATTS Laboratory has established protocols to handle a wide array of PK study designs. Our goal is to achieve rapid turnaround with quality results for a reasonable cost.

 

  • Extensive experience in drug discovery and development

  • Expertise with both small molecules and biologics

  • Excellent technical capabilities

  • Established IACUC protocols for PK Studies in small animals

  • We can assist with:

  • Pharmacokinetic and bio distribution studies in small animals

  • Custom study design

  • Species:

  • Rodents (rat and mouse)

  • USDA regulated animals (guinea pig, hamster, ferret and rabbit)

  • Drug Administration Routes:

  • IP, IV, IM, SC, PO

  • Arterial

  • Continuous infusion using mechanical or osmotic pumps

  • Nasal mucosa, nasal cavity or tracheal/ bronchial (including aerosol inhalation)

  • Study Design can include the following:

  • Single or repeat dose administration

  • Continuous infusion

  • Tissue collection with or without perfusion to determine bio distribution

 

Bio analysis

  • BATTS Laboratories had established strong working relationships with reputable bio analytical companies to efficiently process and analyze samples from our PK studies. We can manage the entire study from drug to report, with a rapid turnaround time and high quality results.

 

Non-GLP and GLP Toxicology Studies

  • Obtaining high quality non-GLP and GLP toxicology data in the early stages of developing a new drug is a critical and cost-effective step in guiding a subsequent GLP toxicology program.

  • Experience in the safety assessment of small molecules and biologics, including dosing, in-life observations, sample collection, and necropsy

  • Established IACUC protocols for toxicology studies in small animals

  • Strong working relationships with clinical labs, histologists and pathologists

 

Additional Custom Services

  • Custom study design

  • Complete study management

  • GLP-style report generation

  • Animal Species

  • Rodents (rat and mouse)

  • USDA regulated animals

  • Drug Administration Routes:

  • IP, IV, IM, SC, PO

  • Arterial

  • Continuous infusion using mechanical or osmotic pumps

  • Nasal mucosa, nasal cavity or tracheal/ bronchial (including aerosol inhalation)

  • Maximum Tolerance and Safety Studies

  • Maximum Tolerated Dose (MTD)

  • Dose Range Finding (DRF)

  • Acute Toxicology

  • Sub Chronic Toxicology (repeated dose)

  • Assessments

  • In-life clinical observations

  • Sample collection for clinical chemistry, hematology, urinalysis, etc.

  • GLP-grade necropsy

  • Histopathology

 

Other Models and In-vivo Services

In addition to efficacy models in oncology, diabetes and wound healing, BATTS Laboratory has extensive experience with many other in vivo experimental models. We have hands-on experience in the following areas:

 

  • Bacterial Infection Models

  • Mouse Subcutaneous Abscess (Skin Infection) Model

  • Mouse Peritoneal Abscess Models

  • Viral Infection Models

  • Delayed Contact Hypersensitization

  • Stereotaxic surgery in mice and rats

  • Transgenic or knockout rodent colony management

  • Maintenance of transgenic or knockout colonies

  • Management of breeding

  • Genotyping

 

 

Support and Resources

In addition to our core suite of contract research services in oncology, diabetes and other disease areas, BATTS Laboratory provides the following adjunct services to support your in vivo studies:

 

  • Available molecular biology lab

  • Available cell culture rooms with BSL-2 and radioactive material capabilities

  • -80°C freezer storage space

  • Environmental Health and Safety support

  • Hazardous waste management

  • BSL-2 waste management

  • Supply procurement

  • IACUC oversight

  • Safety training

  • Clinical Chemistry

  • CBC

 

 

Vivarium Services

BATTS Laboratory operates in vivo pharmacology research vivaria in Los Angeles, California. Our research facilities feature state-of-the-art equipment and caging systems. Our staff is well-trained and friendly. The laboratory serves as a core animal facility for the biotech and pharmaceutical companies to use.

 

  • Exclusive or share-use vivarium rooms of various sizes are available to house your laboratory animals. Support facilities include well-equipped procedure and necropsy rooms, cell culture rooms, a molecular biology laboratory, and a conference rooms. Our scientific team is available to provide technical and surgical assistance on an as-needed basis.

  • By using our vivarium services, clients will save money on equipment, personnel and management costs, and can quickly adapt as their in vivo research needs change.

 

  • Vivarium includes:

  • NIH assurance

  • USDA registration

  • IACUC review provided

  • Experienced attending veterinarian

  • Individually ventilated, cages

  • Biosafety Level-2 safety cabinets

  • Spacious procedure rooms

  • Dedicated necropsy room

  • Available colony and breeding management service, including genotyping

  • Available technical and surgical support from our research scientists

  • Cell culture and molecular biology labs

 

Consumer products testing  

  • Dermal Toxicity

  • Dermal Irritation 

  • Oral Toxicity 

  • Ocular Irritation 

  • Guinea Pig Sensitization 

  • Acute Inhalation 

  • Other Services 

  • Dermal LD50

  • Oral LD50 

  • Ocular Irritation 

  • Guinea Pig Sensitization 

  • Acute Inhalation 

  • Dermal Irritation

  • Mucosal Irritation

  • SPF

  • Photostability

  • Pet products

  • Cosmetics Safety and efficacy: lotions, creams, over the counter cosmoceuticals, mascara, etc.

     

© 2016 All Rights Reserved.